Although the DASH Dietary Approaches to Stop Hypertension diet has been shown to lower blood pressure BP in short-term feeding studies, it has not been shown to lower BP among free-living individuals, nor has it been shown to alter cardiovascular biomarkers of risk. To compare the DASH diet alone or combined with a weight management program with usual diet controls among participants with prehypertension or stage 1 hypertension systolic BP, — mm Hg; or diastolic BP, 85—99 mm Hg. Randomized, controlled trial in a tertiary care medical center with assessments at baseline and 4 months. Enrollment began October 29, , and ended July 28, The main outcome measure is BP measured in the clinic and by ambulatory BP monitoring. Secondary outcomes included pulse wave velocity, flow-mediated dilation of the brachial artery, baroreflex sensitivity, and left ventricular mass. Clinic-measured BP was reduced by For overweight or obese persons with above-normal BP, the addition of exercise and weight loss to the DASH diet resulted in even larger BP reductions, greater improvements in vascular and autonomic function, and reduced left ventricular mass. In addition to advocating weight reduction, physical activity, dietary sodium reduction, and moderation of alcohol consumption, as recommended by earlier guidelines, 2 JNC-7 endorses the DASH Dietary Approaches to Stop Hypertension diet for patients with elevated BP.
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PREMIER is a research study that tested the effects of comprehensive and simultaneous lifestyle changes on blood pressure. Weight loss, exercise, and a healthy diet each reduce blood pressure and control hypertension without medication. This study showed that people with above-optimal blood pressure, including stage 1 hypertension, can successfully make multiple lifestyle changes that lower blood pressure. Together, these lifestyle changes should substantially lower the risk of heart disease and other chronic diseases, including diabetes, osteoporosis, and perhaps cancer.
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